Showing posts with label Round #3. Show all posts
Showing posts with label Round #3. Show all posts
IVF Round 3: Done & Dusted

Our IVF cycle has come to an end.

Egg retrieval yesterday was a bloody nightmare. I was in SO much pain during the four hour wait pre-op, and could hardly walk by the end. After four (!) attempts to find a vein for a cannula, they finally got me sedated {did nothing} and after an excruciating egg retrieval, I had 13 eggs retrieved. All was well, I was happy with that.
Unfortunately I had no response to pain medication after the procedure, and was shaking head to toe. They tried a few drugs, and ended up giving me Endone, which settled things down. After a little while in recovery, they got me up and dressed and finishing off my IV drip - and then I came over really nauseous. Felt like I was about to throw up, broke out in head to toe sweat, face as white as a sheet, and they had to wheelchair me back to recovery, as I was on the brink of passing out. That passed, and we tried getting up to go again - and it happened again.
As such, they admitted me upstairs to the ward for monitoring. I just wanted to go home, but they were worried - so after a few hours of being observed, and just a few more episodes, they let me leave. I slept well last night, and feel better today - just swollen and sore, but that's to be expected after egg retrieval.
We got the call this morning that we have 8 embryos that have survived. I was disappointed, and was greedily hoping for more, after the discomfort I've had the last few weeks of stimming. Knowing we were doing a freeze all, I figured the more embryos the better. Anyway... that said, from 13 we had 2 immature, and 3 that fertilised abnormally - so left with 8 that are in the freezer. The embryologist has frozen them in batches of 3, 3 and 2 for future growing with frozen cycles.
I've had so many people ask me why my clinic has frozen the fertilised embryos at Day 1 - most people are surprised they're not growing them out to day 3 or 5 before freezing. I still have my doubts about it all too, but it's out of my hands. It's done now. Our journey is over.
So... that's it. Feels so strange to have nothing to hope for or to look forward to. No transfer. No TWW. Just pain & discomfort for what seems like a whole lot of nothing. I'm already petrified those embryos will fail to thaw, or die off during the 5-day growing period, when the time comes to use them. There's just no relaxing on this journey.
Now we wait. 
If I had $1 for every time we had to wait during this journey, I'd be a millionaire & IVF costs would mean nothing to me.

Lowering the OHSS Risk

Another day, another frustrating development in this seemingly hopeless IVF cycle.

I spoke to my fertility specialist today. She rang to confirm the freeze-all and to answer a few questions that I had, which I appreciated. After egg retrieval, they will freeze any viable embryos that have fertilised on Day 1. No growing them out, no freezing at blastocyst stage - just bunches of early embryos. Apparently this is because the early embryos are stronger when it comes to thawing and re-freezing, but it worries me a little. At least with blasties, you know only the good ones have made it this far. The problem I can see with the Day 1 embryos, is that we could potentially lose most/all of them when they're growing them out at the time of transfer. Frustrating.

So once I have retrieval, I should get a period within 7-10 days thanks to the Lucrin trigger. That next cycle, which will be December, is a mandatory rest cycle, so no transfer. My FS has told me to go ahead and take Letrozole/Femara days 3-7 that month, to make sure that I ovulate and that it's a relatively short cycle. It's basically a month of 'just see what happens trying yourself' - ha, yeah, right! And then pigs flew out of my butt-crack. Then after my NEXT period, I can ring them and start the ball rolling for a FET in January. January! It feels like a million years away.

She also let me know that she's worried I will hyper-stimulate. Not because of my follicles going too crazy (they only saw 14 after all, which is well within normal range) but because of the fact that the E2 jumped from 686 to 8407 in just three days. As such, I had to drive back down to the clinic at lunch time today to collect an alternate trigger. Instead of the Ovidrel hcg trigger, I'm now taking a Lucrin trigger. She said this should keep me out of OHSS territory, so I'm happy she was looking out for me.

So the trigger is tonight at 10.30pm, and then I have one more day to wait - joy! Egg retrieval is booked for lunchtime on Thursday. All of our hopes lie in some good quality, mature eggs being retrieved - and a bunch would be nice, since we're freezing them all.

This is the only thing I have left to hope for, since everything else has been taken away... so please, please, PLEASE universe, give us a good haul. I'm desperate for our future baby to be inside one of these {very uncomfortable} follicles!

It's a Freeze All

Day 6: E2 was 495 & progesterone 4.4
Day 8: E2 was 686 & progesterone 3.6
Day 11: E2 was 8000 (!!!) & progesterone 5.3

Unfortunately, our cycle is going to be a freeze all. I was quietly holding out a little hope after the progesterone dropped - but obviously the boost in the follicles has resulted in the progesterone level jumping too. Bugger. BUGGER.

The ultrasound today showed 14 follicles, not that I anticipate anywhere near that number at egg collection - but we have a few more to play with, which is nice. I'm glad the E2 levels are matching the scan now, too. The wait is on to see whether those follicles will hold mature, strong eggs.

So we are triggering tomorrow, and having egg retrieval on Thursday. And then, that's it for the year. They'll freeze whatever they get... and we wait until January to plan any transfers. There will be no more pregnancy attempts in 2014. :(

Shit, I hope we get a few good, strong embryos from this. My heart just can't handle any more disappointment.

An Update

So just to REALLY mess with my head, I sent the clinic a message yesterday asking about the numbers, since I hadn't heard. Got this about Friday:
Hi Aly, Yesterday E2 was 686 and P4 was 3.6. Sorry you didn't get a message. (On Wednesday, E2 was 495 and P4 was 4.4.) 
So it's dropped again. Surely that means it must have been residual progesterone levels from the chemical pregnancy last month? And what does it all mean? I guess we'll find out on Monday.

Our Antagonist Protocol

We're still in the early days of this new cycle, so I figured I'd give you a heads up on what we're trying this time.

If you remember back to 2012, our first two IVF cycles were long down-regulation ones: you take the pill, you take Lucrin/Synarel to lull your body into shut-down mode, and then start pumping in the FSH drugs to stimulate the bejesus out of your ovaries. (You know, if your ovaries decide to play ball.) Both cycles, I had low egg numbers - 5 at first retrieval, 3 at the second retrieval.
Obviously we still got REALLY lucky with that last cycle, since all 3 fertilised and we got our Georgia from there -not to mention our two frozen blastocysts that both implanted, but weren't meant to be. 
Our specialist decided we'd try a different protocol this time around - so we're doing an Antagonist cycle. This time, we skipped the birth control and down regulation, and just headed straight into stimming with FSH drugs on CD2.
I'm on 200 of Puregon this cycle, and added in 250 of Orgalutran (Ganirelex) which is to suppress ovulation. The shots are still no problem, though the double whammy stung a bit this morning & my belly is bruised already - and it's only been a few days!
We have bloodwork done tomorrow, but I don't expect to hear results from the clinic unless the numbers are really low, or really high. If average, we just carry on until Friday, when we do more bloods and our first ultrasound to see how the follicles are responding.

I really, really hope we get better numbers this time! :)

It's Over.. but it's Beginning Again

I'm relieved (happy? sad? devastated?) to say that yesterday at 5.5 weeks pregnant {in theory} the miscarriage officially started. Levels had dropped earlier this week, so I was waiting anxiously for something to happen. On Monday, hcg was 17 & progesterone was 10. By Thursday, they were < 2 and the bleeding started. I'm no longer pregnant.

This has been the longest few weeks of my life, honestly. I'm mentally exhausted. But I really am relieved. I know the baby has been gone for a while now, but I feel like I have a little more closure now that it's happened, you know?
The first time around, the actual loss itself was harder - being that much further along, having seen the baby's heart beating and bonded with them already. This time, it's a bit strange. Nobody wants to talk about it with me, I guess they just don't know what to say. But even though it's earlier, the disappointment is just the same. The hopes being crushed, well, that doesn't get any easier with time, or experience.

But... there's a silver lining to everything happening on its own, and not dragging out too long.
Today is CD2, and I started jabbing with the Puregon this morning. I've never done an antagonist (short) cycle before, so I'm really excited to just get on with things - no long down regulation, no birth control, just getting the show on the road.

I've never been happier to stick myself with pointy needles! :)

I'm hopeful that we might do okay this time around. Maybe one of these eggs can lead to our baby.





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